How M.E. was never associated with Fatigue.
Stonebird is delighted to post this important summary by Jerrold Spinhirne The early description ME by E.D. Acheson in 1959, based on careful observation of 14 outbreaks of the disease, did not mention fatigue of any kind as a commonly observed or diagnostically useful symptom: "All the outbreaks shared the following characteristics: (1) headache; (2) myalgia; (3) paresis [muscle weakness, partial paralysis]; (4) symptoms or signs other than paresis suggestive of damage to the brain, spinal cord or peripheral nerves; (5) mental symptoms; (6) low or absent fever in most cases; (7) no mortality. In addition, (1) a higher attack frequency in women; (2) a predominantly normal cerebrospinal fluid, and (3) relapses have occurred in almost all outbreaks. In eleven of the fourteen epidemics symptoms which suggest activity of the disease have persisted for months or years in a few cases, and in eight instances there was an apparent predilection for the nursing or medical professions. L